cancer mesothelioma
History Breaf of Hyperthermia
The healing effect of heat treatment was already mentioned in the advanced cultures of ancient Egypt (2400 BC), but only by medical professionals of Greek antiquity used such method consistently recognized him and called over-heating (in Greek hyperthermia). "Give me the power to produce fever and cure all diseases, "said Parmenides, Greek physician, 540-480 BC
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Hyperthermia (also called thermal therapy or thermotherapy) is an acute illness that occurs when the body produces or absorbs more heat than it can dissipate. Usually it is caused by prolonged exposure to high temperatures. The heat of the regulatory mechanisms of the body eventually overwhelmed and unable to effectively deal with the heat, making that body temperature to climb uncontrollably.
Hyperthermia can also be created artificially by drugs or medical devices. In these cases it can be used to treat cancer and other conditions. Cancer cells are more sensitive to heat than healthy cells and structure reacts differently to overheating. In 1910, the possibility of overheating, in order to increase the effect of radiation in malicious tumors was first described. This is already known and applied method was rediscovered as so-called "whole body hyperthermia" in the beginning of the 1960s. Since the 70s a series of studies were conducted to investigate more fund this form of therapy.
Research has shown that high temperatures (up to 44 ° C) can damage and kill cancer cells, so usually with minimal injury to normal tissues. By killing cancer cells and damaging proteins and structures within cells, hyperthermia may shrink tumors.
Hyperthermia is almost always used with other forms of cancer therapy, such as radiotherapy and chemotherapy. Can make hyperthermia some cancer cells more sensitive to radiation damage cells or cancer other than radiation can not hurt. When combined hyperthermia and radiation, often given within an hour apart. Hyperthermia can also enhance the effects of certain anticancer drugs, which is mutually strengthened and thus more likely a cure – so-called synergistic effect of hyperthermia. It was found that cytostatic drugs (chemotherapy) clearly act more aggressively in temperatures above 40 ° C in the range of normal body temperature.
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